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July 15, 2025
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Microsoft develops medical AI tool better than doctors at diagnosing health conditions

Microsoft has developed a new medical AI tool, which it claims can ‘sequentially investigate and solve medicine's most complex diagnostic challenges’ that even expert physicians struggle to answer.

‘Benchmarked against real-world case records published each week in the New England Journal of Medicine, we show that the Microsoft AI Diagnostic Orchestrator (MAI-DxO) correctly diagnoses up to 85% of NEJM case proceedings, a rate more than four times higher than a group of experienced physicians. MAI-DxO also gets to the correct diagnosis more cost-effectively than physicians,’ Microsoft said.

‘How does AI perform To answer this, we created interactive case challenges drawn from the NEJM case series – what we call the Sequential Diagnosis Benchmark (SD Bench). This benchmark transforms 304 recent NEJM cases into stepwise diagnostic encounters where models – or human physicians – can iteratively ask questions and order tests. As new information becomes available, the model or clinician updates their reasoning, gradually narrowing toward a final diagnosis. This diagnosis can then be compared to the gold-standard outcome published in the NEJM.’ it added.

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